Notice Special Interest NOSI): Implementation Science Advance United States HIV Prevention Treatment Goals the Global HIV Prevention Treatment Targets Notice Number: NOT-MH-20-024 Key Dates Release Date: March 30, 2020 First Available Due Date: 07, 2020 Expiration Date: 08, 2023 Related Announcements PA-20-144, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R01 Clinical Trial Optional) PA-20-145, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R21 Clinical Trial Optional) PA-20

Notice Special Interest NOSI): Mental Health Comorbidities HIV Prevention Treatment Notice Number: NOT-MH-20-013 Key Dates Release Date: March 30, 2020 First Available Due Date: 07, 2020 Expiration Date: 08, 2023 Related Announcements PA-20-144, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R01 Clinical Trial Optional) PA-20-145, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R21 Clinical Trial Optional) PA-20-141, Formative Pilot Intervention Research Prevention Treatment HI

Notice Special Interest NOSI): Strengthening HIV Care Continuum Notice Number: NOT-MH-20-023 Key Dates Release Date: March 30, 2020 First Available Due Date: 07, 2020 Expiration Date: 08, 2023 Related Announcements PA-20-144, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R01 Clinical Trial Optional) PA-20-145, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R21 Clinical Trial Optional) PA-20-141, Formative Pilot Intervention Research Prevention Treatment HIV/AIDS R34 Clinical

Notice Special Interest: Stigma Other Social Determinants Health SDOH) HIV Prevention Treatment Notice Number: NOT-MH-20-020 Key Dates Release Date: March 30, 2020 First Available Due Date: 07, 2020 Expiration Date: 08, 2023 Related Announcements PA-20-144, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R01 Clinical Trial Optional) PA-20-145, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R21 Clinical Trial Optional) PA-20-141, Formative Pilot Intervention Research Prevention

The purpose of this Funding Opportunity Announcement (FOA) is to support high risk, high impact, early discovery research on vaccine approaches to prevent acquisition of or ongoing infection by HIV. In keeping with the high risk, high impact nature of this research, this FOA supports a Go/No-Go approach to funding high risk research, which is significantly different from most R01 projects. Continued funding for the full award duration is dependent upon achieving negotiated Go/No-Go criteria by the end of Year 2.

Notice Special Interest: Developmentally Tailored HIV Prevention Care Research Adolescents Young Adults Notice Number: NOT-MH-20-035 Key Dates Release Date: April 1, 2020 First Available Due Date: 07, 2020 Expiration Date: 08, 2023 Related Announcements PA-20-144, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R01 Clinical Trial Optional) PA-20-145, Innovations HIV Prevention, Testing, Adherence Retention Optimize HIV Prevention Care Continuum Outcomes R21 Clinical Trial Optional) PA-20-141, Formative Pilot Intervention Research Prev

The purpose of this Funding Opportunity Announcement (FOA) is to promote research to understand the underlying mechanisms of sleep deficiencies among health disparity populations and how sleep deficiencies may lead to disparities in health outcomes.

Notice Special Interest NOSI): Cannabis, Prescription Opioid, Prescription Benzodiazepine Drug Among Older Adults Notice Number: NOT-DA-20-014 Key Dates Release Date: April 22, 2020 First Available Due Date: June 05, 2020 Expiration Date: September 08, 2023 Related Announcements PA-19-055- NIH Research Project Grant Parent R01 Clinical Trial Required) PA-19-056- NIH Research Project Grant Parent R01 Clinical Trial Allowed) PA-19-091 NIH Research Project Grant Parent R01 Basic Experimental Studies Humans Required) PA-19-052: NIH Small Research Grant Program Parent R03 Clinical Trial Allowed)

Notice Special Interest NOSI): Advancing Research SUD through Computational Neuroscience Notice Number: NOT-DA-20-022 Key Dates Release Date: 05, 2020 First Available Due Date: June 05, 2020 Expiration Date: September 08, 2023 Related Announcements PAR-19-368 R01) Accelerating Pace Drug Abuse Research Using Existing Data Clinical Trial Optional) PA-19-054 Parent R21) NIH Exploratory/Developmental Research Grant Program Clinical Trial Required) PA-19-053 Parent R21) NIH Exploratory/Developmental Research Grant Program Clinical Trial Allowed) PA-19-092 Parent R21) NIH Exploratory/Developmenta

The goals of this Funding Opportunity Announcement (FOA) are to stimulate further research on delineating the pathophysiology of HIV-1 associated CNS disease in the setting of chronic viral suppression and ART. In addition, FOA also encourages research studies to aid in the identification/ validation of biomarkers and pre-clinical targets with quantifiable readouts in domestic and international settings. Multidisciplinary research teams and collaborative alliances are encouraged but not required.