January 18, 2023 - An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined. The HPX3002/HVTN 706, or “Mosaico,” Phase 3 clinical trial began in 2019 and involved 3,900 volunteers ages 18 to 60 years in Europe, North America, and South America. Based on the DSMB’s recommendation, the study will be discontinued. Participants are being notified of the findings, and further analyses of the study data are planned.
January 5, 2023 — NIH scientists and partners developed technology to provide a genome-wide expression profile of cells harboring latent HIV, which could enable the search for new HIV cure strategies that target infected cell reservoirs.
October 21, 2022 — Starting antiretroviral treatment (ART) early in the course of HIV infection when the immune system is stronger results in better long-term health outcomes compared with delaying ART, according to findings presented today at the IDWeek Conference in Washington, D.C. The findings are based on an extended follow-up of participants in the National Institutes of Health-funded Strategic Timing of Antiretroviral Treatment (START) study.
October 20, 2022 — A three-dose course of the hepatitis B vaccine HEPLISAV-B fully protected adults living with HIV who had never been vaccinated against or infected with the hepatitis B virus (HBV), according to study findings presented today at the IDWeek conference in Washington, D.C. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, sponsors the ongoing Phase 3 ACTG A5379 clinical study.
NIH Announces Additional Funding Awards for Ending the HIV Epidemic Initiative Implementation Research Projects
October 6, 2022 — Last month, as part of their support of the Ending the HIV Epidemic in the U.S. (EHE) initiative, NIH announced 66 awards to institutions participating in the NIH-funded Centers for AIDS Research (CFAR) and the NIMH AIDS Research Centers (ARC) programs. This was the fourth year of NIH investments in EHE-focused research projects. These new awards total $26 million and will support research in 33 of the EHE priority jurisdictions to strengthen research-community collaborations and enhance the implementation science knowledge base needed to end the HIV epidemic.
August 26, 2022 — The National HIV/AIDS Strategy (NHAS) Federal Implementation Plan reflects the collaborative work of representatives from 10 federal departments and details more than 380 action items they will implement individually and collaboratively. This plan documents federal agencies’ commitments to programs, policies, research, and other activities needed to meet the NHAS goals. These critical activities, which encompass work to for fiscal years 2022–2025, will move our indicators of progress in the right directions.
July 27, 2022 — In a presentation today at AIDS 2022, the 24th International AIDS Conference in Montreal, scientists with the National Institute of Allergy and Infectious Diseases’ (NIAID) Vaccine Research Center (VRC) and their collaborators described how their use of cutting-edge technology revealed new insights into cellular reservoirs of HIV and what those observations could mean for the next steps in HIV cure research. NIAID is part of the National Institutes of Health.
July 22, 2022 — An NIH-funded team has found that patterns of sugars at the surface of our own human immune cells affect their vulnerability to HIV infection.
June 15, 2022 — Nearly all cases of anal cancer are caused by infection with cancer-causing types of HPV.
June 9, 2022 — access issue of the Journal of Acquired Immunodeficiency Syndrome (JAIDS) will highlight HIV implementation science findings, reported by scientists and implementations teams funded by the National Institutes of Health through the Ending the HIV Epidemic initiative. (JAIDS)
May 12, 2022 — A new study shows how community engagement approaches developed by the HIV Vaccine Trials Network strengthened COVID-19 vaccine trials.
Transactional sex, HIV and health among young cisgender men and transgender women who have sex with men in Thailand
April 8, 2022 — Study examines how recent sex work is identified and the HIV risk factors and service needs among Thai cisgender men who have sex with men and transgender women who exchange sex. (Elsevier: Annals of Epidemiology)
March 14, 2022 — Phase 1 study is among first to examine mRNA technology for HIV.
February 15, 2022 — Woman has remained without detectable HIV for 14 months
January 2022 – Moderna announces the launch of human clinical trials for an experimental HIV vaccine that uses the same kind of mRNA technology found in Moderna’s COVID-19 vaccine. (The Hill)
December 21, 2021 — Approval marks pivotal expansion of HIV prevention options in the United States.
December 9, 2021 — NIH scientists developed vaccine platform.
November 2021 — Includes 14 articles on Innovations in Methods and Measurement Science on the Social Determinants of HIV. (AIDS and Behavior).
November 30, 2021 — NIH-funded study estimates global progress toward UNAIDS goal.
October 29, 2021 — Different mechanisms suppressed the virus in each person.
July 22, 2021 — The National Institutes of Health has renewed grants to seven regional centers that compose the International epidemiology Databases to Evaluate AIDS (IeDEA), awarding $20.8 million in first-year funding. The 15-year-old IeDEA program efficiently advances knowledge about HIV by pooling and analyzing de-identified health data from more than two million people with HIV on five continents to answer research questions that individual studies cannot address. The grants are expected to last five years and to total an estimated $100 million.
June 9, 2021 — Mobile clinics could serve as an innovative strategy for expanding access to care.
April 22, 2021 — The National Institute of Health (NIH) recognizes that ending the HIV epidemic will require eliminating HIV-related stigma, which continues to be a critical barrier to the uptake of evidence-based HIV interventions, and in this article the authors provide an overview of NIH HIV stigma research and findings. (AIDS and Behavior)
April 8, 2021 — The COVID-19 pandemic is affecting people with or at risk for HIV indirectly and direct.
April 7, 2021 — Effective responses to concurrent COVID-19 and HIV/AIDS pandemics require a novel coordinated and collaborative global effort to accelerate biomedical research and implementation science to operationalize evidence-based interventions expeditiously. (The Journal of Infectious Diseases)
Profile: Fogarty Fellow Dr. Joseph Matovu investigates HIV self-testing in Ugandan fishing community
March/April 2021 – When social network leaders were trained to disseminate HIV self-testing kits, more than 95% were properly used and returned. (NIH Fogarty International Center Global Health Matters Newsletter, Image courtesy of Moses Mayombwe)
March 31, 2021 — Concerns about access to Covid-19 vaccines in Africa resemble concerns raised about responding to the HIV pandemic in the mid-1990s and early 2000s, when highly active antiretroviral treatment was accessible in high-income countries but limited in African countries. (The New England Journal of Medicine)
March 29, 2021 — Lessons learned from a Request for Applications that called for methodological innovations around the social determinants of HIV and provided a unique opportunity to reflect on the state of the science. (AIDS and Behavior)
March 12, 2021— Dr. Carl Dieffenbach, director of the Division of AIDS at NIH’s National Institute of Allergy and Infectious Diseases, and his colleague Dr. Hillary Hoffman, joined HIV.gov for a conversation about the latest HIV prevention and treatment research presented during the 2021 Conference on Retroviruses and Opportunistic Infections. (HIV.gov)
Unique genotypic features of HIV-1 C gp41 membrane proximal external region variants during pregnancy relate to mother-to-child transmission via breastfeeding
January 2021 - Findings from a pilot study on mother-to-child transmission (MTCT) of HIV-1 through breastfeeding raise the possibility for predicting MTCT by breastfeeding based on identifying mothers with high-risk viral populations. (Journal of Clinical Pediatrics and Neonatology)
Tuesday, January 26, 2021 – Results of Antibody-Mediated Prevention Studies funded by the NIH’s National Institute of Allergy and Infectious Diseases will inform development of long-acting antibody-based HIV prevention tools. (Image Credit: NIAID)
February 19, 2021 — Expert report cites unequal progress in Southern U.S. and among marginalized groups.